DNA_ligase_A_N: DNA ligase N terminus
| PAG Title | DNA_ligase_A_N: DNA ligase N terminus |
| PAG ID | PEX000958 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1). It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I (Swiss:P18858), and in Saccharomyces cerevisiae (Swiss:P04819), this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus (Swiss:P16272) this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation 1. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 384 |
| Information Content | Rich |
| Other IDs | PF04675 |
| Base PAG ID | PEX000958 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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